Modeling Particle Shape-Dependent Dynamics in Nanomedicine

Modeling particle shape-dependent dynamics in nanomedicine.

One of the major challenges in nanomedicine is to improve nanoparticle cell selectivity and adhesion efficiency through designing functionalized nanoparticles of controlled sizes, shapes, and material compositions. Recent data on cylindrically shaped filomicelles are beginning to show that non-spherical particles remarkably improved the biological properties over spherical counterpart. Despite ...

Modeling cell shape and dynamics on micropatterns

Adhesive micropatterns have become a standard tool to study cells under defined conditions. Applications range from controlling the differentiation and fate of single cells to guiding the collective migration of cell sheets. In long-term experiments, single cell normalization is challenged by cell division. For all of these setups, mathematical models predicting cell shape and dynamics can guid...

Shape Modeling and Analysis with Entropy-Based Particle Systems

This paper presents a new method for constructing compact statistical point-based models of ensembles of similar shapes that does not rely on any specific surface parameterization. The method requires very little preprocessing or parameter tuning, and is applicable to a wider range of problems than existing methods, including nonmanifold surfaces and objects of arbitrary topology. The proposed ...

Modeling of Rumen Particle Dynamics in Dairy Cows Fed Sugarcane

ISOGEOMETRIC STRUCTURAL SHAPE OPTIMIZATION USING PARTICLE SWARM ALGORITHM

One primary problem in shape optimization of structures is making a robust link between design model (geometric description) and analysis model. This paper investigates the potential of Isogeometric Analysis (IGA) for solving this problem. The generic framework of shape optimization of structures is presented based on Isogeometric analysis. By discretization of domain via NURBS functions, the a...